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Immunogen
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Background
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.
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Target protein
Recommended dilution
| Application | Dilution |
|---|---|
| FC | 1:200 - 1:400 |
| IF | 1:200 - 1:1000 |
| IHC | 1:200 - 1:1000 |
| WB | 1:500 - 1:2000 |
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