Rb Monoclonal Antibody

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Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: IHC-p, IF, ELISA

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Applications: IHC-p, IF, ELISA

Product overview

Full product name

Retinoblastoma-associated protein

Code

BT-MCA1094

Host

Mouse

Isotype

IgG

Size

50ul,100ul

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of human Rb expressed in E. Coli.

Purification

Affinity purification

Concentration

1 mg/ml

Formulation

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Storage

-20°C for one year

Background

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Uniprot accession

Human:;Mouse:;

Molecular weight

N/A

Gene ID

Human: 5925

Synonyms

RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Research area

Cancer; Cell biology; Epigenetics and nuclear signaling

Target protein

RB1

Recommended dilution

Application	Dilution
ELISA	1:10000
IHC	1:200 - 1:1000

Images

Immunohistochemistry staining of paraffin-embedded human normal esophagus (A) and stomach (B) tissue, showing nucleus localization with DAB staining using Rb Monoclonal antibody.

Protocols

> Protocol Booklet

Customer reviews and Q&As

No reviews

Datasheet

Product size

Price

50ul

$180.00
100ul

$300.00

Add to Cart

Lead time: Within one week

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